New Delhi:
According to a research article, the reference to Genomindia Project-India reference to the dataset genetics and genomics for genetics and genomics can help improve how the disease is diagnosed.
Launched by the Department of Biotechnology in 2020, Genomindia aims to build a database that captures the genetic diversity of India’s population.
In the first phase, genomes of 10,000 individuals were indexed, whose data was published in January this year for future research.
Writing in a comment published in the Journal of Nature Genetics Journal, researchers from more than 20 institutions, including Center for Scientific and Industrial Research (CSIR) and All India Institute of Medical Sciences, have published initial findings of genomic sequencing.
Kumarasamy Thangraj, CSIR BHATNAGAR Fellow, Hyderabad, Hyderabad, in CSIR-Centire for Cellular and Molecular Biology, Hyderabad told PTI, “The comment was written to the scientific community that India has completed the entire genome sequencing of 10,000 persons. The team has fulfilled the Indo-Yutik and Termocian, Dravidian and Termocian, Dravidian, Draw Saw four major linguistic groups. Within a broad geographical area, the population related to different bio-geologists was taken.
In addition, about 160 unrelated people of each non-turbulent group were indexed to genomes and 75 of each tribal group.
Researchers identified the genetic variants, which described the broad genetic diversity “unacceptored in the Indian population”.
This task is a good start, the first sequencing of population-pamana sequencing in India, Thangraj said, “In response to a question about the smaller fraction of the genome, compared to the country’s population.
In addition, “the model that the genomindia project has created to analyze the genomes of Indians will be useful for future large -scale research projects in the country.”
The efforts of genomindia in the manufacture of a dataset representative of Indians are similar to the purpose of creating a standard ‘Indian reference genome’ in the UK (UK Biobank) and Europe.
“Yes, (dataset) is of the same type, but what is interesting is that being one of the oldest population next to the Africans, the Indians are unique in their origin and therefore, the genetic profile,” said Thangraj.
A person’s genome can be compared against the standard to identify the difference and ‘gene variants’, or turns into someone’s DNA sequence. The theory forms the basis of genome-wide association studies, which helps to understand and prevent and treat the genetic base of a disease or characteristic in a population.
Thangraj said, “Some of these variants may be associated with the disease, while others provide information about how a drug is metabolized in a person’s body. Therefore, when we complete the in -depth analysis of the indexed genome, we will get information about all these aspects,” Thangraj said.
He said that the findings of the ongoing analysis could be expected to be published in a magazine reviewed by a colleague by the end of this year.
Comment says, “Intensive analysis of 9,772 diverse genomes with blood biochemistry and anthropometry data will improve the disease diagnosis, predict the genetic base of drug responses, and kick-start procedural medicine efforts in India.” Compared to previous studies, “Genomindia’s sample strategy is wider, fine and balanced in relation to ethnic, socio-cultural, geographical, bio-science and linguistic diversity,” said the authors, compared to previous studies.
Genomindia is also expected to “facilitate genetic union studies of future in the country”.
The need for a dataset representative of the Indian population has been felt since decades, as research around the world is largely based on the European population, which offers huge bias in the results and conclusions of the study.
However, now, the cost of sequencing a genome, India’s technical and technical capacity and advances in government support are some factors that have come together, assisting this national representative in the development of genetic databases, Thangraj said.
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